Few dishes say comfort food quite like meatloaf. It’s hearty, familiar, and deeply satisfying. But when you take that classic and infuse it with Italian flavors—think herbs, garlic, tomato glaze, and a molten mozzarella center—you get something truly special. Italian Mozzarella Stuffed Meatloaf is the kind of recipe that feels both nostalgic and exciting, perfect for weeknight dinners, Sunday family meals, or even casual entertaining.

This recipe is completely original, crafted to balance bold Italian flavors with the cozy appeal of traditional meatloaf. The real star is the mozzarella hidden inside, which melts as the meatloaf bakes, creating a creamy, cheesy center that stretches beautifully with every slice. Paired with a savory tomato glaze and aromatic herbs, this dish delivers maximum flavor without complicated steps.

In this guide, you’ll learn not just how to make Italian mozzarella stuffed meatloaf, but why each step matters, how to customize it, and how to serve it for different occasions. Whether you’re a beginner cook or a seasoned home chef, this recipe is designed to be reliable, flexible, and crowd-pleasing.

Why You’ll Love This Italian Mozzarella Stuffed Meatloaf

Cheesy surprise inside: The mozzarella center adds richness and visual appeal.
Italian-inspired flavor: Garlic, herbs, and tomato glaze elevate classic meatloaf.
Family-friendly: Familiar flavors that both kids and adults enjoy.
Make-ahead friendly: Perfect for meal prep or busy schedules.
Versatile: Easy to customize with different meats or cheeses.

Ingredients for Italian Mozzarella Stuffed Meatloaf

Use fresh, good-quality ingredients for the best results. This recipe strikes a balance between juiciness and structure, ensuring slices hold together while staying tender.

Meatloaf

1 ½ pounds ground meat (beef, or a beef/pork blend)
1 cup Italian-style breadcrumbs
2 large eggs
½ cup milk
1 small onion, finely diced
3 cloves garlic, minced
½ cup grated Parmesan cheese
2 tablespoons chopped fresh parsley
1 teaspoon dried oregano
1 teaspoon dried basil
1 teaspoon salt
½ teaspoon black pepper

Stuffing

8 oz fresh mozzarella, cut into thick sticks or slices

Tomato Glaze

¾ cup marinara or tomato sauce
2 tablespoons ketchup
1 tablespoon olive oil

Step-by-Step Instructions

Preheat and Prepare
Preheat your oven to 375°F (190°C). Line a baking sheet with parchment paper or lightly grease a loaf pan. Using a lined baking sheet allows excess fat to drip away for a lighter meatloaf.
Mix the Base
In a large bowl, combine breadcrumbs and milk. Let them soak for about 1 minute until softened. This step ensures a moist meatloaf.
Add Flavorings
Add eggs, onion, garlic, Parmesan, parsley, oregano, basil, salt, and pepper to the breadcrumb mixture. Stir gently until combined.
Incorporate the Meat
Add the ground meat to the bowl. Mix with your hands just until combined. Avoid overmixing, which can make the meatloaf dense.
Shape and Stuff
Divide the meat mixture in half. Shape the first half into a flat oval on the prepared baking sheet. Arrange mozzarella sticks lengthwise down the center, leaving space at the edges.
Seal the Meatloaf
Place the remaining meat mixture on top and gently press the edges together, sealing the mozzarella completely inside. Shape into a loaf.
Add the Glaze
In a small bowl, mix marinara sauce, ketchup, and olive oil. Spread evenly over the top of the meatloaf.
Bake
Bake uncovered for 50–60 minutes, or until the internal temperature reaches 160°F (71°C).
Rest and Slice
Let the meatloaf rest for 10 minutes before slicing. This helps the cheese set slightly and keeps slices neat.

Tips for the Perfect Mozzarella Stuffed Meatloaf

Seal the edges well: Prevent cheese from leaking by fully enclosing the mozzarella.
Use low-moisture mozzarella: It melts beautifully without releasing too much liquid.
Rest before slicing: This is key for clean slices and better texture.
Don’t overmix: Gentle mixing keeps the meatloaf tender.

Variations and Customizations

Different Meats:
Try ground turkey or chicken for a lighter version. Add a tablespoon of olive oil to maintain moisture.

Cheese Swaps:
Provolone, fontina, or even smoked mozzarella add new flavor dimensions.

Spicy Italian Meatloaf:
Add crushed red pepper flakes or chopped Calabrian chilies to the meat mixture.

Gluten-Free Option:
Use gluten-free breadcrumbs or rolled oats.

Serving Suggestions

Italian mozzarella stuffed meatloaf pairs beautifully with classic sides:

Creamy mashed potatoes or garlic mashed cauliflower
Roasted vegetables like zucchini, carrots, or bell peppers
Simple green salad with balsamic vinaigrette
Buttered pasta or polenta for an Italian-inspired meal

Leftovers make excellent sandwiches the next day—just add extra marinara and a toasted roll.

Make-Ahead, Storage, and Reheating

Make-Ahead:
Assemble the meatloaf up to 24 hours in advance and refrigerate before baking.

Storage:
Store leftovers in an airtight container in the refrigerator for up to 4 days.

Reheating:
Reheat slices in the oven at 325°F (165°C) or gently in the microwave.

A Little Cultural Context

Meatloaf may be rooted in American home cooking, but Italian cuisine has long embraced baked meat dishes like polpettone. This Italian mozzarella stuffed meatloaf draws inspiration from that tradition, blending comfort food with Mediterranean flavors and cheese-forward indulgence.

Final Thoughts

Italian Mozzarella Stuffed Meatloaf is proof that classic comfort food doesn’t have to be boring. With its savory Italian seasoning, rich tomato glaze, and irresistible cheesy center, this dish earns a permanent spot in your recipe rotation. It’s approachable enough for a weeknight, yet impressive enough to serve guests.

Once you slice into that melted mozzarella, you’ll understand why this recipe quickly becomes a family favorite.